Epsteinbarr virusassociated with lymphoepithelial carcinoma. Jul 15, 20 primary lymphoepithelial like carcinoma of the parotid gland is a rare tumour with an increased incidence among eskimos and orientals. Lymphoepitheliomalike carcinoma lelc of the salivary gland is a rare tumor. The study of lymphoepithelial carcinoma has been mentioned in research publications which can be found using our bioinformatics tool below. Lymphoepitheliomalike carcinoma of head and neck skin. Lymphoepithelial carcinoma is a rare tumor of the salivary gland of exceptionally high incidence among eskimo. Primary lymphoepithelial carcinoma of the nasopharynx. Lymphoepitheliomalike carcinoma lelc is a medical term referring to a histological variant of malignant tumor arising from the uncontrolled mitosis of transformed cells originating in epithelial tissue or in cells that display epithelial characteristics that bear microscopic resemblance to lymphoepithelioma nasopharyngeal carcinoma.
Pdf background lymphoepithelial carcinoma is a tumor mostly diagnosed in the nasopharynx, but it has also been described in a. Lymphoepithelial carcinoma lec is an uncommon malignant neoplasm characterized by undifferentiated malignant epithelial cells with marked infiltration of lymphoid cells in the stroma. Pdf primary cutaneous lymphoepitheliomalike carcinoma is a rare disease with low metastatic potential. Four others had foci of both lec and conventional squamous cell carcinoma.
Lymphoepithelial carcinoma lec of the larynx is a neoplasm that is located in most of the cases in the nasopharynx, where it represents 40% of all tumors. Rare pdf lymphoepithelial carcinoma lec is most commonly seen in the nasopharynx. Lymphoepithelial carcinoma of the salivary glands ncbi. Conclusion lymphoepithelial like carcinoma occurring in the reproductive organs is a rare variant of squamous cell carcinoma, and this tumor of the uterine cervix accounts for 0, 7% of all primary cervical uterine neoplasms. Two subsets of gastric cancer, epsteinbarr virus ebvpositive and microsatellite instability msihigh cancers, have been. Epsteinbarr virusassociated lymphoepithelial carcinoma has been exceptionally reported. The lymphoepithelial carcinoma of the nasopharynx is strongly associated with infection with the epsteinbarr virus ebv. Pdf lymphoepithelial carcinoma of parotid gland a case. Histology showed a well circumscribed lesion composed of syncytial sheets of epithelioid tumour cells with an intense inflammatory infiltrate, largely consisting of t lymphoid cells. It constitutes about 4% of all gastric carcinomas 3, 4.
Pdf lymphoepithelial carcinoma lec is most commonly seen in the nasopharynx. Lymphoepithelial carcinoma of the parotid gland, head. Lymphoepithelial carcinoma, which is a variant of undifferentiated carcinoma, is distinguished from small cell and large cell undifferentiated carcinoma by its association with benign lymphoepithelial lesions. Furthermore for the salivary plec have been used different terms as. The histogenesis of lelcs remains controversial as to whether it has adnexal origin or represents an inflamed squamous cell carcinoma scc histology of lymphoepitheliomalike carcinoma. A multicenter analysis of genomic profiles and pdl1. In western countries, salivary gland lymphoepithelial like carcinomas are uncommon and only 14 cases have been described so far. Lymphoepithelial carcinoma affects children and adults and presents at a mean age of approximately 55 years. Controversies exist in the current literature regarding the treatment of lymphoepithelial carcinoma lec. A majority of lymphoepithelial carcinoma originates from the nasopharynx, but some will involve the lung, salivary glands, stomach, urinary tract. However, in contrast to other highgrade salivary gland carcinomas, lelcs are considered radiosensitive. Lymphoepitheliomalike carcinoma of the skin lelcs is a very rare primary skin neoplasm that most frequently occurs on the sunexposed skin of the head and neck in elderly individuals.
In this case report, we discuss its etiopathogeny, its epidemiological, clinical. Lymphoid lesions of salivary glands lymphoid lesions of salivary glands. Lymphoepithelial carcinoma schmincke type as a derivate. Lymphoepitheliomalike carcinoma llc of the stomach is a rare and peculiar type of gastric carcinoma that was first described by watanabe et al in 1976 as gastric carcinoma with a lymphoid stroma 1, 2. We report a case of a lymphoepithelial carcinoma developing in a minor salivary gland of the oral cavity in a 69yearold woman. Lymphoepitheliallike carcinomas of the head and neck are histologically similar to nasopharyngeal carcinoma nonkeratinizing undifferentiated type but by definition arise in mucosal sites other than the nasopharynx. Although such tumours are well described in the cervix this is only the second report of such a neoplasm at this site. We report a case of a 76yearold woman, presented with a primary lymphoepithelial carcinoma of the parotid gland. The treatment for lymphoepithelial carcinoma of salivary gland involves a combination of surgery, chemotherapy, and radiation therapy, in most cases. The tumor they described could be the first reported case of lymphoepithelial carcinoma. Lymphoepithelial carcinoma of the larynx is an extremely rare disease, with an aggressive pattern. Dec 14, 2014 lymphoepitheliomalike carcinoma is a rare tumor of the bladder for which the therapeutic strategy is not clearly defined.
Lymphoepithelial carcinoma of the lacrimal gland external. The ulcerations represent punch biopsies figure 2 an invasive carcinoma originates from the epidermis and pen. Lymphoepitheliallike carcinoma of the parotid gland. Dec 11, 2012 lymphoepithelial carcinoma of the maxillary sinus is a very rare malignancy and it can be difficult to make a preoperative diagnosis. Although clinically significant because of its malignant nature, it is difficult to make a differential diagnosis by preoperative imaging. The tumor showed no evidence of recurrence or metastasis at clinical follow.
Our first case is a 30yearold man with lec in the left maxillary sinus. The lesion is histologically identical to undifferentiated nasopharyngeal carcinoma lymphoepithelioma, but with epsteinbarr virus involvement. Lymphoepitheliallike carcinomas of the head and neck. Strong nuclear staining with erg in lymphoepitheliomalike carcinoma immunohistochemical stain. The patient was then referred to the oncology team for further management in view of postoperative. Lymphoepitheliomalike, a variant of urothelial carcinoma.
Thymoma is only rarely reported within the thyroid gland. Investigations revealed a muscleinvasive lymphoepitheliomalike carcinoma of the bladder. Pdf lymphoepithelial carcinoma of the salivary glands. Epsteinbarr virus negative lymphoepithelial carcinoma of. Lymphoepitheliomalike carcinoma of the salivary gland. Pathology outlines lymphoepitheliomalike carcinoma. Ep415 lymphoepithelial cervical carcinoma international.
Lymphoepitheliomalike carcinoma of the vagina journal. However, it can also occur in other organs including the salivary glands, particularly the parotid and submandibular glands. Lymphoepithelial carcinoma malignant lymphoepithelial lesion. Lymphoepithelial carcinoma arising from the maxillary antrum. We report the case of a 64yearold moroccan man who presented with macroscopic hematuria. Pdf lymphoepithelial carcinoma of parotid gland a case report. The patient was disease free for four years then she had primary lung recurrence which was surgically resected. Most cases of lymphoepithelial carcinoma behave as intermediate to highgrade malignancies. Download this article belongs to volume 25, issue 1. Lymphoepitheliomalike carcinoma pathology dermnet nz. Therefore, it must be known by clinicians, pathologists and oncologists.
Lymphoepithelial carcinoma of the minor salivary gland jama. Lymphoepithelial carcinoma lec is a rare variant of undifferentiated carcinoma that accounts for less than 0. Jun 23, 2011 lymphoepithelial carcinoma lec is a rare malignancy. Lymphoepitheliomalike carcinoma lelc of the prostate. A case of lymphoepithelial carcinoma lec occurring in right submandibular gland of a yearold indian male is presented, wherein the lesion unveiled itself only after multiple fine needle.
Well circumscribed lobules, nests or small aggregates of large, cohesive, epithelioid cells closely associated with a dense, mixed t and b lymphocytic and plasmacytic infiltrate rare tumors 20. First reported in 1991, bladder lelc has an incidence of about 1% of all bladder carcinomas. Lymphoepithelioma an overview sciencedirect topics. Lymphoepitheliomalike carcinoma of the bladder is an uncommon neoplasm, of which 49 cases have been described in the english literature, none of which has been studied for p53 protein expression. The prognosis of the individual depends upon a set of several factors including the tumor stage and overall health of the individual. Endoscopic excision of the tumor was performed and the final histological examination was compatible with sinonasal lymphoepithelial carcinoma. In these populations, it is usually associated with epsteinbarr virus. Lymphoepithelial carcinoma lec of the oral cavity and pharynx is uncommon, and the.
A 72yearold caucasian woman presented to our facility with an isolated rightside epistaxis that had been present for three months, with the results of a computed tomography scan showing a soft tissue mass in the right maxillary sinus with an impacted tooth. Lymphoepitheliomalike carcinoma of the prostate request pdf. Primary lymphoepitheliallike carcinoma of the parotid. Herein, we report two cases of lec in the head and neck region that presented to oulu university hospital. Adjunct professor, university of utah school of medicine. The histogenesis of lelcs remains controversial as to whether it has adnexal origin or represents an inflamed squamous cell carcinoma scc. Primary lymphoepithelial carcinoma plec is a rare subtype of salivary gland cancers, which comprises only 0. Lymphoepithelioma is a type of poorly differentiated nasopharyngeal carcinoma characterized by prominent infiltration of lymphocytes in the area involved by tumor.
Currently, surgery with or without radiotherapy is the recommended treatment for all salivary gland carcinomas. Due to its rare occurrence, prognoses and ideal treatment guidelines have not been clearly defined. Lymphoepithelial carcinoma is a rare variant of anaplastic carcinoma, that accounts for less than 0. Researched pathways related to lymphoepithelial carcinoma include pathogenesis, localization, cell differentiation, oncogenesis, immune response. Primary lymphoepithelial carcinoma plec is a very unusual subtype of salivary gland cancers, which involves mainly the parotid gland1,2. Lymphoepithelial carcinoma lec is a rare malignancy with the histopathological feature of undifferentiated carcinoma and an intermixed reactive lymphoplasmacytic infiltration. Primary lymphoepitheliallike carcinoma of the parotid gland. Lymphoepithelial carcinoma lec is a rare malignancy with the. Poorly differentiated nonkeratinizing squamous cell carcinoma of the thymus, also known as lymphoepitheliomalike carcinoma, is a rare primary malignant neoplasm of. Lec can occur in many organs, but is most common in head and neck regions including pharynx. Lymphoepitheliomalike carcinoma lelc is a rare highgrade carcinoma that resembles nasopharyngeal lymphoepithelioma and can occur throughout the body.
He is currently on clinical surveillance, showing no signs of active disease at 9 months of followup. Lymphoepitheliomalike carcinoma of the skin lelcs is a rare tumor of unknown etiology, low malignant potential, and microscopic resemblance to. Lymphoepithelial carcinoma of the larynx and hypopharynx. The majority of cases involve the parotid gland, presenting as single or multiple masses.
Ibrahimov m, yilmaz m, celal mh, mamanov m, yollu u, ozek h. Lymphoepitheliomalike carcinoma is a rare tumor of the bladder for which the therapeutic strategy is not clearly defined. Magnetic resonance imaging revealed a large well defined symmetrical soft tissue mass lesion arising from the mucosa of the nasopharynx. This is a case of metastatic lung cancer of the lymphoepitheliallike carcinoma lelc variant who first presented with symptomatic brain metastasis. All eight tumors exhibited alterations in p53 expression, but none was positive for.
The most common location of lec is the nasopharynx. Cytokeratin positive derived from the kidney parenchyma gata3 is expressed not associated with epsteinbarr virus in contrast to nasopharyngeal carcinoma. Case report epsteinbarr virus associated lymphoepithelial. Lymphoepithelial carcinoma of the maxillary sinus is a very rare malignancy and it can be difficult to make a preoperative diagnosis. Pdf lymphoepitheliomalike carcinoma of the skin researchgate. Nov 25, 2017 lymphoepithelial carcinoma is a tumor mostly diagnosed in the nasopharynx, but it has also been described in a variety of nonnasopharyngeal sites. Lymphoepithelial carcinoma lec, also called lymphoepitheliomalike carcinoma, is defined as an undifferentiated carcinoma or poorly differentiated squamous cell carcinoma, accompanied by a prominent reactive lymphoplasmacytic infiltrate. In the present article, we describe in detail the clinical and histopathologic features of a primary lacrimal gland lymphoepithelial carcinoma with immunohistochemical and molecular analysis. Histologically, it is an undifferentiated carcinoma with an intermixed reactive lymphoplasmacytic infiltrate.
Its morphologic and pathological features are similar to those of nasopharyngeal lymphoepithelial carcinoma. There is strong association with epsteinbarr virus ebv infection. Lymphoepitheliomalike carcinoma of the bladder lelcb is a rare variant of urothelial carcinoma first described by zukerberg in 1991 and confirmed as a variant of urothelial carcinoma by the who classification of tumors of the urinary system. Primary lymphoepitheliallike carcinoma of the parotid gland is a rare tumour with an increased incidence among eskimos and orientals. Lymphoepithelial carcinoma is a tumor mostly diagnosed in the nasopharynx, but it has also been described in a variety of nonnasopharyngeal sites.
Lymphoepithelial like carcinomas of the head and neck are histologically similar to nasopharyngeal carcinoma nonkeratinizing undifferentiated type but by definition arise in mucosal sites other than the nasopharynx. The presented study summaries the literature controversies in the treatment of lec and present a case of a rare lec diagnosed in the sublingual gland of an otherwise healthy 21yearold arab woman. A form of cancer, carcinoma makes up the majority of the cases of malignancy of the breast, uterus, intestinal tract, skin, and tongue. Lymphoepithelial carcinoma is a large cell undifferentiated carcinoma embedded within a dense lymphoid stroma. Lelcb is characterized by a marked infiltration of lymphocytes in the area involved by the tumor which may coexist with the conventional urothelial. Investigations revealed a muscleinvasive lymphoepitheliomalike carcinoma of. Most cases of lec occur in the nasopharynx and are pathologically classified as a nonkeratinizing undifferentiated type of nasopharyngeal.
Lymphoepithelial carcinoma lec is an uncommon malignant tumor composed of undifferentiated malignant epithelial cells with characteristic lymphoid stroma. The patient underwent local and systemic treatment for metastatic disease with good clinical outcome. Lymphoepitheliomalike carcinoma of the vagina journal of. E590 14 cases of the renal pelvis, including 7 case reports and 2 small case series. Lymphoepithelial carcinoma definition of lymphoepithelial. Pdf lymphoepithelial carcinoma of the submandibular. There are only a few published reports of radiotherapy alone for the treatment of. Lymphoepithelial carcinoma of salivary glands lymphoepithelial carcinoma of salivary glands abdulla, abdel. This report describes a lymphoepitheliomalike carcinoma of the vagina. Lymphoepithelial sialadenitis, hivassociated salivary gland disease, chronic sclerosing sialadenitis, warthin tumor, and extranodal marginal. Lymphoepithelioma is also known as class iii nasopharyngeal carcinoma in the who classification system.
The prognosis of lelc is thought to be better than those of other cervical cancer types, but careful followup at fixed. However, no risk factor is known for lelc of the bladder 4. There are only a few published reports of radiotherapy alone for the treatment. Lymphoepitheliomalike carcinoma of the skin can j plast surg vol 10 no 5 novemberdecember 2002 221 figure 1lymphoepitheliomalike carcinoma of the skin on the upper arm of a 38yearold woman just before excisional biopsy. He is now at 9months followup period, with no evidence of disease. Ten tumours of tonsillar or epipharyngeal localization showing the histological picture of lymphoepithelial carcinoma schmincke 1921 were examined immunohistochemically using peanut lectin, ulex europaeus lectini and an antiserum to s100 protein. Expression of pdl1pd1 in lymphoepitheliomalike carcinoma. Skin nonmelanocytic tumors lymphoepitheliomalike carcinoma. Lymphoepithelial carcinoma arising from the maxillary. Lymphoepithelial carcinoma of the minor salivary gland. In this communication a case of thymic carcinoma with lymphoepithelial. The findings suggest a close relationship of this type of carcinoma to the normal tonsillar crypt epithelium. It has a high tendency to metastasize and is responsive to radiotherapy.
Lymphoepitheliomalike carcinoma, abbreviated lelc, is a rare, poorly differentiated, malignant epithelial tumour it can be considered a subtype of squamous carcinoma aka squamous cell carcinoma. Poorly differentiated nonkeratinizing squamous cell carcinoma of the thymus, also known as lymphoepitheliomalike carcinoma, is a rare primary malignant neoplasm of thymic origin. Who gets lymphoepithelial carcinoma of salivary gland. It is extremely rare in the larynx and should be distinguished from squamous cell carcinoma. Lymphoepithelial carcinoma of parotid gland a case report.
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